The pathogenesis of autoimmune disease
The pathogenesis of autoimmune disease has a new human cytomegalovirus can induce low-intensity persistent inflammation
By the Peking University People's Hospital Professor Li Zhanguo team and the Academy of Military Medical Sciences, Professor Yang Guang, a group of research completed a new study - human cytomegalovirus changes in natural killer cells steady state can induce autoimmune diseases, recently in the "cell" Cell Host Microbe ". The study in the international community for the first time to answer the cytomegalovirus and some autoimmune diseases associated with the common mechanism. Liu Yu assistant researcher, Mu Rong chief physician and Gao Yaping senior experimental division is the first author of the paper.
Li Zhiguo introduction, human cytomegalovirus (hCMV) is a can infect people and pathogenic cytomegalovirus, often quietly lurking in the human body, even if the body's powerful immune system, can not be killed or cleared. Once the body immunity decreased, it began to active, wantonly copy and invade the human body, leading to the occurrence of autoimmune diseases. US autoimmune related disease data show that about 1/6 of people suffering from autoimmune diseases. In China, autoimmune disease is included in the national long-term scientific and technological development program of one of the 10 major diseases.
Mu Rong, the previous study found that human cytomegalovirus and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren's syndrome (pSS) and other autoimmune diseases related to the incidence, but its mechanism is unclear. The study used phage display technology to find a new specific antibody from RA, SLE and pSS sera, which may be induced by pp150 protein in hCMV. Natural killer cells (NK) surface markers are divided into CD56bright and CD56dim groups. The anti-pp150 antibody recognizes CD56bright natural killer cells (NK) on the surface of the tumor suppressor protein CIP2A, induced complement-dependent cytotoxicity, killing human CD56brightNK cells, resulting in reduced NK cells in patients, and NK cell imbalance is leading to autoimmune diseases An important mechanism of disease.
The study demonstrated that hCMV can induce low-intensity persistent inflammation by influencing the steady state of NK cells, deepen the understanding of the pathogenesis of autoimmune diseases, and discover new potential therapeutic targets, to understand the phenomenon of autoimmune The rational treatment of disease is of great significance